Como você está ? ( How are you ? ) :

Como você é ? Como você está ?
The two questions above translated as "What are you like ?" ( Como você é ? ) and "How are you ?" ( Como você está ?). 
In English, both questions use the verb to be, but in Portuguese the difference between them is conveyed using "ser" in the first one ( which asks about someone's characteristics) and "estar" in the second ( which asks about a temporary state or condition). While the question "Como você é?" may be asked at a job interview or on a date, in order to know the person better, the question "Como você está?" may be a greeting or a request for information about someone's state of health or state of mind.
Ref: (Beginner's Brazilian Portuguese)